ŠĻą”±į>ž’ HJž’’’G’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’’ģ„Į šæ!bjbjąą ,J‚j‚j’’’’’’lŅŅŅŅŅŅŅ6bbb8š ¦¤6A¶VV"xxxxxxĄĀĀĀĀĀĀ$÷ !ŚęŅxxxxxę*ŅŅxxū***xHŅxŅxĄ*xĄ*²*ÜŅŅÜxJ š¢żM2Ä6,bĄjÜÜä0AÜń!*ń!Ü*ę."ŅŅŅŅŁMeeting of the Research Advisory Committee on Gulf War Veterans’ Illnesses U.S. Department of Veterans Affairs October 27 and 28, 2003 VA Central Office, 810 Vermont St., Washington D.C. Room 630  Preliminary Agenda Monday, October 27, 2003 8:30 – 8:45 Welcome, introductions, opening remarksMr. Jim Binns8:45 – 9:30Birth Defects and Pregnancy Outcomes Following Service in the Gulf War Dr. Araneta, Assistant Professor at the University of California at San Diego, will present information from her studies on birth defects in children of Gulf War veterans. Her presentation will include the first release of the results from her study “Conception and Pregnancy During the Persian Gulf War: The Risk to Women Veterans” to be published in the November, 2003, issue of Annals of Epidemiology. Dr. Happy Araneta9:30 – 10:15Information From a Registry of Birth Defects in Children of Gulf War Veterans Ms. Mekdeci is Executive Director of Birth Defects Research for Children, a non-profit organization that maintains a registry of children of Gulf War veterans with birth defects. She will present data from the registry, as well as preliminary information from a cooperative study of Goldenhar Syndrome in children of Gulf War veterans. Ms. Betty Mekdeci10:15 – 10:30 Break10:30 – 11:15 Findings on Birth Defects from the National Survey of Gulf War Veterans Dr. Kang is Director of VA’s Environmental Epidemiology Program and the War-Related Injury and Illness Study Center in Washington, D.C. He will present new results on birth defects from VA’s National Survey of Gulf War Veterans, including medical record corroboration of birth defects reported by Gulf Veterans. Dr. Han Kang11:15 – 11:45 Discussion 11:45 – 12:00 Update on Published ResearchDr. Lea Steele12:00 – 1:00Lunch 1:00 – 1:45 NTE and Identification of Possible Molecular Targets of Neurotoxic Exposures in Gulf War Veterans Dr. Barlow, currently with Merck Research Laboratories, will present work conducted with colleagues at Salk Institute that demonstrated the effects of nerve agents and organophosphate pesticides on neuropathy target esterase (NTE) and the role of differences in the NTE gene. This research may have profound implications for our understanding of the effects of these chemicals on humans exposed to them. Dr. Barlow will outline the potential for genomics research to identify targets for treatments, of potential benefit to both ill Gulf War veterans and others at risk of future terrorist or military chemical attack. Dr. Carrolee Barlow1:45 – 2:30 Neurotoxins and Gulf War Illness: An Overview of VA’s Research Enhancement Award Program (REAP) Dr. Wilson, VA Senior Research Career Scientist and Professor of Pharmacology at Duke University, will describe the work of VA’s Neurotoxins and Gulf War Illness Program, which will examine proteins expressed in patient and animal samples following exposure to neurotoxins. This research has the potential to identify biomarkers that identify exposed individuals, as well as molecular targets for treatment interventions. Dr. Wilkie Wilson 2:30 – 2:45 Break2:45 – 4:30 Update on VA Gulf War Illness Research Programs Dr. Wray is VA’s Chief Research and Development Officer, and will update the committee on recently-funded deployment health studies. She will also present information on plans for VA’s Neuroimaging Resource Center and the Gulf War illness pilot project from the San Francisco VA. Dr. Nelda Wray VA Study of AChE-R in Gulf War Veterans Dr. Soreq, of Hebrew University in Jerusalem, and Dr. Concato, Chief of Epidemiology at the West Haven VA, will present initial results of a VA study to determine whether ill Gulf War veterans have high levels of a mutant form of the enzyme acetycholinesterase (AChE-R), shown in previous studies to be associated with exposures to AChE-inhibiting chemicals such as those encountered during the Gulf War. Her laboratory has also developed a novel treatment that may be effective in treating this abnormality. Dr. Hermona Soreq Dr. John Concato4:30 – 5:00 Public Comment5:00Adjourn for the day Preliminary Agenda Tuesday, October 28, 2003 8:30 – 9:45 Department of Defense Research on Gulf War Veterans’ Illnesses and Chemical Defense Representatives will present information on DOD’s research on Gulf War illnesses and deployment health, and an overview of DOD research relating to medical chemical defense. DOD speaker tba9:45 – 10:30 Additional Findings from the VA ALS Study and Update on the ALS Registry Dr. Oddone, Director of the Health Services Research Center at Duke University, and Principle Investigator of VA’s study of ALS in Gulf War Veterans, will present more detailed results of analyses from that study, and will update the committee on VA’s ALS Registry. Dr. Eugene Oddone 10:30 – 10:45 Break10:45 – 11:15 Monitoring the Health of Gulf War Veterans Using Existing VBA Data Systems Ms. Perez is Assistant Director for Data and Information Services at the Office of Performance Analysis and Integrity at VA’s Veterans Benefits Administration. She will present information on benefits claims data resources and how they might be used to monitor the health of Gulf War veterans. Ms. Susan Perez11:15 – 11:45 Monitoring the Health of Gulf War Veterans Using VHA Data and Information Resources Dr. Hynes directs the VA Information Resource Center, and will present information on the databases and resources available at VA’s Veterans Health Administration, and how they might be used to monitor Gulf veterans’ health and clinical care. Dr. Denise Hynes11:45 – 12:15 Q&A, Discussion 12:15 – 1:15 Lunch 1:15 – 2:00 Anthrax Vaccinations and Health Outcomes in the National Survey of Gulf War Veterans Dr. Kang will present results from VA’s National Survey of Gulf War veterans on a subgroup of veterans known to have received the anthrax vaccine in association with Gulf War deployment. 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